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Urban Dictionary "Opa":

It is a word or pronouncement of celebration; the celebration of life itself. It is another way of expressing joy and gratitude to God, Life, and others, for bringing us into the state of ultimate wisdom; that all that really matters is health, family, and friends. It is a humorous affirmation that you're the best; that you're where you're supposed to be; and that you need to stop and celebrate. It is the Greeks' way of stating they have come to a level of serene exuberance able to enjoy life as children.